Shotaro Michinaga Selected Research

Brain Edema (Cerebral Edema)

1/2023	Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury.
1/2021	Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice.
1/2020	Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between bosentan and ambrisentan.
1/2018	Delayed Administration of BQ788, an ETB Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood-Brain Barrier Function and a Reduction of Cerebral Edema in Mice.
1/2017	The Endothelin ETB Receptor Antagonist BQ788 Protects against Brain Edema after Fluid Percussion Injury by Decreasing Vascular Endothelial Growth Factor-A Expression in Mice.
9/2015	Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A.
1/2014	Amelioration of cold injury-induced cortical brain edema formation by selective endothelin ETB receptor antagonists in mice.
1/2012	Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains.

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Shotaro Michinaga Research Topics

Disease

8	Brain Edema (Cerebral Edema) 01/2023 - 01/2012
6	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2023 - 01/2018
3	Narcolepsy 01/2012 - 01/2010
2	Type 2 Diabetes Mellitus (MODY) 01/2024 - 04/2022
2	Insulin Resistance 04/2022 - 01/2022
2	Brain Diseases (Brain Disorder) 01/2019 - 04/2013
2	Nervous System Diseases (Neurological Disorders) 01/2018 - 01/2010
2	Cold Injury 09/2015 - 01/2014
2	Edema (Dropsy) 04/2015 - 01/2014
2	Parkinson Disease (Parkinson's Disease) 01/2012 - 12/2010
1	Inflammation (Inflammations) 03/2024
1	Non-alcoholic Fatty Liver Disease 01/2024
1	Hyperglycemia 01/2024
1	Insulinoma 01/2024
1	Metabolic Diseases (Metabolic Disease) 01/2024
1	Glucose Intolerance 01/2024
1	Neuroinflammatory Diseases 01/2023
1	Gliosis 01/2019
1	Hypersensitivity (Allergy) 09/2018
1	Atopic Dermatitis (Atopic Eczema) 09/2018
1	Brain Ischemia (Cerebral Ischemia) 12/2012
1	Sleepiness 01/2012
1	Sleep Wake Disorders 01/2012
1	Disorders of Excessive Somnolence (Hypersomnia) 12/2010

Drug/Important Bio-Agent (IBA)

5	Endothelins (Endothelin)IBA 01/2023 - 01/2014
5	BQ 788IBA 01/2020 - 01/2014
3	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 01/2022
3	Endothelin-1 (Endothelin 1)IBA 01/2021 - 01/2018
3	Evans Blue (Blue, Evans)FDA Link 01/2021 - 01/2014
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 01/2012
3	OrexinsIBA 01/2012 - 01/2010
2	FR 139317IBA 01/2018 - 01/2014
2	Matrix Metalloproteinases (MMPs)IBA 09/2015 - 01/2012
2	IRL 2500IBA 09/2015 - 01/2014
2	Dopamine Agonists (Dopamine Agonist)IBA 01/2012 - 12/2010
2	ropinirole (Requip)FDA LinkGeneric 01/2012 - 12/2010
2	NeuropeptidesIBA 12/2010 - 01/2010
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2024
1	GTP-Binding Proteins (G-Protein)IBA 03/2024
1	JNK Mitogen-Activated Protein KinasesIBA 03/2024
1	Proteins (Proteins, Gene)FDA Link 03/2024
1	Phosphotransferases (Kinase)IBA 03/2024
1	MitogensIBA 03/2024
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 03/2024
1	ArrestinsIBA 03/2024
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2024
1	Indicators and Reagents (Reagents)IBA 01/2024
1	1-Acylglycerophosphocholine O-Acyltransferase (1 Acylglycerophosphocholine O Acyltransferase)IBA 01/2024
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2024
1	CytokinesIBA 01/2023
1	Histamine AgonistsIBA 11/2022
1	LipidsIBA 01/2022
1	Endothelin Receptor AntagonistsIBA 01/2020
1	ambrisentan FDA Link 01/2020
1	Angiopoietin-1IBA 01/2020
1	Bosentan (Tracleer)FDA Link 01/2020
1	Vasoconstrictor AgentsIBA 01/2019
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	Toluene 2,4-Diisocyanate (Toluene Diisocyanate)IBA 09/2018
1	Neutralizing AntibodiesIBA 01/2017
1	Claudin-5IBA 01/2017
1	Messenger RNA (mRNA)IBA 09/2015
1	Blood Proteins (Serum Proteins)IBA 04/2015
1	AlbuminsIBA 01/2014
1	Glial Fibrillary Acidic ProteinIBA 01/2014
1	ChemokinesIBA 04/2013
1	Vascular Endothelial Growth FactorsIBA 12/2012

Therapy/Procedure

1	Phototherapy (Light Therapy) 09/2018
1	Intravenous Administration 01/2018